Tell your veterinarian if your pet is being given aspirin; another NSAID such as etodolac, carprofen, or piroxicam; any over-the-counter cough, cold, allergy, or pain medication; warfarin; furosemide; a steroid such as prednisone; insulin; or probenecid. Drugs other than those listed may also interact with Rimadyl. Talk to your veterinarian before giving your pet any prescription or over-the-counter medicines.
Carprofen should not be used in pets with bleeding disorders such as Von Willebrand disease or those with low platelet counts, or in pets that are allergic to it or other NSAIDs in the same class. It should be used cautiously in pets younger than 6 weeks of age, older pets, pregnant or lactating pets, dehydrated pets, or pets with pre-existing diseases, especially liver, kidney, heart, or gastrointestinal disease. It should be used cautiously in pets that have had bone surgery or injury, as carprofen may affect bone healing. Carprofen should be used cautiously, if at all in cats, or in pets taking other NSAIDs or corticosteroids.
The following medications should be used with caution when given with carprofen: anticoagulants, ACE inhibitors, aspirin or other NSAIDs, corticosteroids, cyclosporine or other nephrotoxic medications, dacarbazine, dactinomycin, desmopressin, digoxin, dinoprost, highly protein bound medications, insulin, oral antidiabetics, loop diuretics, methotrexate, or tricyclic antidepressants.
Prior to starting carprofen, baseline bloodwork and urinalysis should be performed by your veterinarian. For long-term carprofen use, liver enzymes and kidney values should be checked 2 to 4 weeks after starting the medication, and then every 3 to 6 months during therapy. At home, monitor for serious side effects, and discontinue the medication and contact your veterinarian if these occur. Your veterinarian may monitor your pet to be sure that the medication is working.
Rimadyl is one of the brand names for the veterinary drug carprofen. Carprofen belongs to a group of drugs called NSAIDs, or nonsteroidal anti-inflammatory drugs. These drugs act to reduce inflammation with fewer negative side effects than steroids, making them more suitable than steroids for long-term use.
The only way for dogs to receive carprofen is with a prescription from their vet. Your vet will determine the proper dosage for your dog and ensure that carprofen is the appropriate medication to help reduce their pain and inflammation.
So, what is carprofen used for in dogs Ultimately, carprofen is a pain relief medication that can make your dog more comfortable despite their ailment. Dogs recovering from surgery, dealing with joint pain, or suffering from other inflammatory issues can all benefit from using carprofen during the recovery process. Here are a few other uses:
Carprofen is commonly used to control soreness and inflammation due to arthritis in dogs and other painful conditions, such as osteoarthritis, which affects the joints.3 However, carprofen can also be used short-term to help manage pain after an injury, such as a car accident or fall.
Of course, some dogs should not take NSAIDs, including those that have had a negative reaction or an allergic reaction to carprofen. They should also not take carprofen with other NSAIDs or corticosteroids.3
Dogs can overdose on carprofen, so pet parents must follow the instructions given to them by their vets. Symptoms of an overdose typically occur in doses of 10mg per pound or more. They can cause severe pain, diarrhea, and vomiting. Overdoses are serious and can be fatal, so if you believe your dog has overdosed on carprofen, take them to the nearest emergency vet.
Carprofen is typically prescribed for long and short-term use to manage pain and inflammation. How long your dog needs to take carprofen will depend on their ailment and the recommendations from your veterinarian.
ConclusionOverall, carprofen is effective in reducing pain in dogs with OA. However, additional benefit can be seen with adjunctive agents. Care should be taken to monitor for signs of adverse effects from the use of carprofen. Clients should be counseled regarding risk reduction with use of this drug, including giving carprofen with food to reduce the risk of GI effects and providing access to plenty of water to reduce risk of renal toxicosis. Clients should be reminded to contact their veterinarian immediately in the event of signs of adverse effects.
Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of inflammation and to provide analgesia. Carprofen appears to have greater activity against the cyclooxygenase-2 (COX-2) isoenzyme than COX-1, which may partly explain why carprofen appears to be less ulcerogenic than many other NSAIDs pharmacokinetics. There is good absorption from the gastrointestinal tract following oral administration. There is a high degree of protein binding and a small volume of distribution that is mostly to extracellular sites. Carprofen is a weak acid, so it readily penetrates into inflamed tissue. Elimination is usually following metabolism by hepatic enzymes, and the less active metabolites are eliminated via a combination of faecal and urinary excretion. Urinary excretion of the unchanged drug is minimal, and relies on glomerular filtration and tubular excretion. There is also a degree of hepatic excretion and evidence of enterohepatic recycling.
If your dog is experiencing pain and inflammation, your veterinarian may prescribe carprofen. This common dog medication works in a similar way to human medications like ibuprofen, but is safe for dogs (unlike ibuprofen and many other human drugs).
I've seen carprofen used in many dogs with great success throughout my career as a veterinary technician. I've also seen some dogs experience undesirable side effects. Now, my own senior dog is taking it to manage her arthritis. It has reminded me that, while carprofen is often safe and effective, it's important to monitor dogs closely while they are on this drug.
Pain from inflammation is facilitated by an enzyme called cyclooxygenase (COX). There are two forms of this enzyme: COX-1 and COX-2. Both facilitate pain and inflammation, but COX-2 is mainly found at sites with swelling. Carprofen is categorized as a selective COX-2 inhibitor, preserving COX-1 in a dog's body which is primarily known to maintain and protect the lining of the gastrointestinal tract. Some NSAIDs inhibit all COX, which is likely to cause stomach upset, ulcers, and bleeding. By inhibiting COX-2 but not COX-1, carprofen can relieve pain and inflammation with milder GI side effects, which is why carprofen and other COX-2 inhibiting NSAIDs are prescribed over other types of NSAIDs for certain dogs
Side effects can occur with any drug, and carprofen is no exception. Like most NSAIDs, gastrointestinal upset is one of the most common side effects. Carprofen is generally tolerated well by dogs when given with food at the appropriate dosage. However, some dogs may still experience some of the following:
Before starting carprofen, your veterinarian may recommend blood tests to assess your dog's health, particularly liver and kidney function. This is because carprofen, like most NSAIDs, can have a negative impact on the liver and kidneys. Follow-up blood tests will be needed after your dog has been on this medication to make sure there are no changes to the liver and kidney values.
My own dog has not had any visible side effects like vomiting or diarrhea, but one of her liver enzymes was slightly elevated on her follow-up blood work. My vet has recommended that we recheck her blood work in a few weeks and also do some X-rays so she can see how her liver looks. If anything is abnormal, she may need an ultrasound. We may even need to stop the medication if they determine that the carprofen is affecting her liver. This scenario is not uncommon for dogs on this drug, so be sure to follow your vet's recommendations about monitoring.
Carprofen should not be given in conjunction with other NSAIDs or corticosteroids. This will increase the likelihood of dangerous side effects like GI bleeding and ulceration, liver damage, and kidney damage. Other drugs can interact with carprofen as well, so tell your vet about all medications and supplements that you give your dog.
It's certainly possible for dogs to overdose on carprofen, and the outcome can be serious. Doses of 10 milligrams per pound or more tend to first cause severe vomiting, abdominal pain, and diarrhea. Left untreated, carprofen toxicity can lead to weakness, tremors, seizures, GI perforation, and kidney failure.
The most common type of overdose happens when a dog gets into a bottle of chewable carprofen and eats the whole thing. This kind of extreme overdose calls for an immediate vet visit or head to an animal emergency center if your vet is closed. Be sure to bring what is left of the pill bottle and any other information available about the drug strength and quantity.
To prevent accidental overdose, be sure to keep carprofen and all other medications out of your dog's reach. Make sure all members of your home understand the dosing instructions and schedule if they will be involved in feeding/medication times.
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the carbazole and propionic acid class that was previously for use in humans and animals, but is now only available to veterinarians for prescribing as a supportive treatment for various conditions in only animals. Carprofen reduces inflammation by inhibition of COX-1 and COX-2; its specificity for COX-2 varies from species to species. Marketed under many brand names worldwide, carprofen provides day-to-day treatment for pain and inflammation from various kinds of joint pain, as well as post-operative pain. 781b155fdc